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Phenotypic Behavioural Effects of Genetic Deletion of the Vesicular Glutamate Transporter 3 in 5-Hydroxytryptamine Neurons.

Genes, brain, and behavior - 1 Aug 2026

Gullino L Sophie, Chabbah Nida, Jayaram Spatika, Pinacho Raquel, El Mestikawy Salah, Daumas Stéphanie, Bannerman David M, Sharp Trevor

Abstract excerpt

A major subpopulation of 5-hydroxytryptamine (5-HT) neurons expresses the vesicular glutamate transporter 3 (VGLUT3) allowing the co-release of glutamate. Previous evidence has implicated VGLUT3 in 5-HT neurons in mechanisms of anxiety and reward. Here we examined mice with a genetic loss of VGLUT3 targeted to 5-HT neurons (VGLUT3 cKO5-HT) and littermate controls in a battery of behavioural tests, including...

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Identifiers

PMID: 42504398
DOI: 10.1111/gbb.70063
PMCID: PMC13402935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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