Article
GAL3 receptor KO mice exhibit an anxiety-like phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2014
Brunner Susanne M, Farzi Aitak, Locker Felix, Holub Barbara S, Drexel Meinrad, Reichmann Florian, Lang Andreas A, Mayr Johannes A, Vilches Jorge J, Navarro Xavier, Lang Roland, Sperk Günther, Holzer Peter, Kofler Barbara
Abstract excerpt
The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems. It is a modulator of various physiological and pathological processes, and it mediates its effects via three G protein-coupled receptors (GAL1-3 receptors). A role for GAL as a modulator of mood and anxiety was suggested, because GAL and its receptors are highly expressed in limbic brain structures of rodents. In...
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