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Article

Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice.

European journal of pharmacology - 7 Feb 2003

Kelley Stephen P, Bratt Alison M, Hodge Clyde W

Abstract excerpt

Anxiety disorders are the most common psychiatric disorders. Typical medications used to treat patients are benzodiazepines or antidepressants that target serotonin (5-HT) activity. The ionotropic 5-HT(3) receptor has emerged as a potential therapeutic target because selective antagonist compounds reduce anxiety in rodents, primates, and humans. 5-HT binds to the extracellular N-terminus of the 5-HT(3A) receptor...

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Source

Identifiers

PMID: 12568911
DOI: 10.1016/s0014-2999(02)02960-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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