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Article

Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice.

Biological research - 19 Sept 2017

González Luis F, Henríquez-Belmar Francisca, Delgado-Acevedo Claudia, Cisternas-Olmedo Marisol, Arriagada Gloria, Sotomayor-Zárate Ramón, Murphy Dennis L, Moya Pablo R

Abstract excerpt

BACKGROUND: Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1-3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate transporter EAAT3 is a strong candidate for this disorder. To evaluate the impact of reduced EAAT3 expression in vivo, we studied male EAAT3 heterozygous and wild-type littermate mice using a...

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Identifiers

PMID: 28927446
DOI: 10.1186/s40659-017-0138-3
PMCID: PMC5605982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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