The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice.

doi:10.1038/s41467-024-49371-1

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Article

The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice.

Nature communications - 7 Jul 2024

Favier Mathieu, Martin Garcia Elena, Icick Romain, de Almeida Camille, Jehl Joachim, Desplanque Mazarine, Zimmermann Johannes, Henrion Annabelle, Mansouri-Guilani Nina, Mounier Coline, Ribeiro Svethna, Henderson Fiona, Geoffroy Andrea, Mella Sebastien, Poirel Odile, Bernard Véronique, Fabre Véronique, Li Yulong, Rosenmund Christian, Jamain Stéphane, Vorspan Florence, Mourot Alexandre, Duriez Philibert, Pinhas Leora, Maldonado Rafael, Pietrancosta Nicolas, Daumas Stéphanie, El Mestikawy Salah

Abstract excerpt

Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh vesicular stores through vesicular synergy. A missense polymorphism, VGLUT3-p.T8I, was identified in patients with substance use disorders (SUDs) and eating disorders (EDs). A...

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PMID: 38971801
DOI: 10.1038/s41467-024-49371-1
PMCID: PMC11227582

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