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Article

Forebrain Lineage Factor DMRTA2 Is Not Required for Maintenance of H3G34-Mutant Paediatric High-Grade Gliomas.

Journal of cellular and molecular medicine - 1 Jul 2026

Bressan Raul B, Sanchez Oliva, Biagi-Junior Carlos Alberto Oliveira de, Torres-Ruiz Raúl, Cruzeiro Gustavo Alencastro Veiga, Salgado Irene, Rodriguez-Perales Sandra, Caleiras Eduardo, Vega Zaira, Morrison Gillian, Pollard Steven M, Filbin Mariella G, Valiente Manuel

Abstract excerpt

Developmental transcriptional programs are increasingly recognized as key drivers of paediatric gliomagenesis. Here, we unexpectedly find that the forebrain-specific doublesex- and mab-3-related transcription factor a2 (DMRTA2), despite being highly expressed in H3G34-mutant diffuse hemispheric glioma (DHG-H3G34) and implicated in tumour initiation, is not required for the maintenance of established...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42502246
DOI: 10.1111/jcmm.71302
PMCID: PMC13401718

Genes

DMRTA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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