Article
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Nature - 29 Jan 2012
Schwartzentruber Jeremy, Korshunov Andrey, Liu Xiao-Yang, Jones David T W, Pfaff Elke, Jacob Karine, Sturm Dominik, Fontebasso Adam M, Quang Dong-Anh Khuong, Tönjes Martje, Hovestadt Volker, Albrecht Steffen, Kool Marcel, Nantel Andre, Konermann Carolin, Lindroth Anders, Jäger Natalie, Rausch Tobias, Ryzhova Marina, Korbel Jan O, Hielscher Thomas, Hauser Peter, Garami Miklos, Klekner Almos, Bognar Laszlo, Ebinger Martin, Schuhmann Martin U, Scheurlen Wolfram, Pekrun Arnulf, Frühwald Michael C, Roggendorf Wolfgang, Kramm Christoph, Dürken Matthias, Atkinson Jeffrey, Lepage Pierre, Montpetit Alexandre, Zakrzewska Magdalena, Zakrzewski Krzystof, Liberski Pawel P, Dong Zhifeng, Siegel Peter, Kulozik Andreas E, Zapatka Marc, Guha Abhijit, Malkin David, Felsberg Jörg, Reifenberger Guido, von Deimling Andreas, Ichimura Koichi, Collins V Peter, Witt Hendrik, Milde Till, Witt Olaf, Zhang Cindy, Castelo-Branco Pedro, Lichter Peter, Faury Damien, Tabori Uri, Plass Christoph, Majewski Jacek, Pfister Stefan M, Jabado Nada
Abstract excerpt
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events underlying this distinction, we sequenced the exomes of 48 paediatric GBM samples. Somatic mutations in the H3.3-ATRX-DAXX chromatin remodelling pathway were identified in 44% of tumours...
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