Article
Histone H3 mutations in pediatric brain tumors.
Cold Spring Harbor perspectives in biology - 1 Apr 2014
Liu Xiaoyang, McEachron Troy A, Schwartzentruber Jeremy, Wu Gang
Abstract excerpt
Until recently, mutations in histones had not been described in any human disease. However, genome-wide sequencing of pediatric high-grade gliomas revealed somatic heterozygous mutations in the genes encoding histones H3.1 and H3.3, as well as mutations in the chromatin modifiers ATRX and DAXX. The functional significance and mechanistic details of how these mutations affect the tumors is currently under...
Topics
- Brain Neoplasms
- Child
- Epigenomics
- Glioma
- Histones
- Humans
- Mutation
- Tumor Microenvironment