Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma.

Nature reviews. Cancer - 1 Oct 2014

Jones Chris, Baker Suzanne J

Abstract excerpt

Diffuse high-grade gliomas (HGGs) of childhood are a devastating spectrum of disease with no effective cures. The two-year survival for paediatric HGG ranges from 30%, for tumours arising in the cerebral cortex, to less than 10% for diffuse intrinsic pontine gliomas (DIPGs), which arise in the brainstem. Recent genome-wide studies provided abundant evidence that unique selective pressures drive HGG in children...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type I
Share to Amino Acid Sequence
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Glioma

Share to Histones

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 25230881
DOI: 10.1038/nrc3811
PMCID: PMC4747023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma.PMID 25230881Read ↗

Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease.Semantic proximity Read ↗

Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape.Semantic proximity Read ↗

Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets.Semantic proximity Read ↗

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade gliomaSemantic proximity Read ↗

Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma.Semantic proximity Read ↗

Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted TherapeuticsSemantic proximity Read ↗

Diffuse intrinsic pontine glioma: current insights and future directionsSemantic proximity Read ↗

A comprehensive review of paediatric low-grade diffuse glioma: pathology, molecular genetics and treatment.Semantic proximity Read ↗

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.Semantic proximity Read ↗

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Mutations in chromatin machinery and pediatric high-grade glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.