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Genetic architecture shared between body shape phenotypes and preeclampsia-related diseases: a genome-wide cross-trait analysis.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology - 1 Dec 2026

Shan Yuping, Hu Hong, Liu Chong, Li Wenting, Chu Yijing

Abstract excerpt

BACKGROUND: Observational studies have established a strong epidemiological connection between obesity and an increased risk of pre-eclampsia (PE). However, the genetic mechanisms underlying this comorbidity remain largely unexplored. In this study, we conducted a comprehensive cross-trait analysis to elucidate the shared genetic architecture between various adiposity-related traits and PE. METHODS: Using the...

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Adiposity
Genetic Pleiotropy
Genome-Wide Association Study
Linkage Disequilibrium
Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42496099
DOI: 10.1080/01443615.2026.2706674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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