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Article

Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations.

Journal of translational medicine - 19 Dec 2025

Jiang Xin, Li Shunqing, Zhang Shimao, Li Juntong, Liu Deliang, Zhao Hengxia

Abstract excerpt

BACKGROUND: Obesity and autoimmune disorders represent a significant comorbidity burden, yet their shared genetic architecture is not fully understood. Elucidating the pleiotropic genetic basis underlying both conditions is crucial for unraveling the mechanisms driving their co-occurrence and advancing therapeutic strategies. METHODS: We conducted a large-scale cross-trait analysis integrating genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41419940
DOI: 10.1186/s12967-025-07422-1
PMCID: PMC12777313

Genes

CD38
CLN3
MMEL1
SH2B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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