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Article

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.

BMC medicine - 11 Feb 2022

Liu Qianwen, Zhu Zhaozhong, Kraft Peter, Deng Qiaolin, Stener-Victorin Elisabet, Jiang Xia

Abstract excerpt

BACKGROUND: The comorbidity between polycystic ovary syndrome (PCOS) and obesity has long been observed in clinical settings, but their shared genetic basis remains unclear. METHODS: Leveraging summary statistics of large-scale GWAS(s) conducted in European-ancestry populations on body mass index (adult BMI, Nfemale=434,794; childhood BMI, N=39,620), waist-to-hip ratio (WHR, Nfemale=381,152), WHR adjusted for BMI...

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Identifiers

PMID: 35144605
DOI: 10.1186/s12916-022-02238-y
PMCID: PMC8832782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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