Article
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.
Genome medicine - 6 Oct 2025
Kim Daeeun, Highland Heather M, Smit Roelof A J, Hysong Micah R, Buchanan Victoria L, Young Kristin L, Zhao Chi, Spracklen Cassandra N, Kilpeläinen Tuomas O, Guo Boya, Darst Burcu F, Cai Yanwei, Wang Zhe, Lundin Jessica, Berndt Sonja I, Manson JoAnn E, Marouli Eirini, Lange Leslie, Lange Ethan, Fornage Myriam, Gignoux Christopher R, Haiman Christopher A, Rich Stephen S, Buyske Steven, Loos Ruth J F, Kooperberg Charles, Peters Ulrike, Avery Christy L, Gordon-Larsen Penny, Graff Mariaelisa, Raffield Laura M, North Kari E
Abstract excerpt
BACKGROUND: Obesity is thought to increase cardiovascular disease (CVD) risk partly through dyslipidemia. Yet, obesity's effects on dyslipidemia are not uniform. Understanding the shared genetic basis between obesity and lipid traits can provide insight into this heterogeneity and its implications for CVD risk. METHODS: We examined local genetic correlations between three lipid measures [high-density lipoprotein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.