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Article

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.

Molecular and cellular endocrinology - 1 Oct 2026

Wang Suijian, Wang Kui

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) frequently co-occurs with obesity, insulin resistance, dyslipidaemia and metabolic syndrome (MetS). However, whether this metabolic burden represents secondary comorbidity or an intrinsic component of PCOS genetic architecture remains unclear. METHODS: We used genomic structural equation modelling to construct female- and male-specific hierarchical MetS latent factors...

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Source

Identifiers

PMID: 42385931
DOI: 10.1016/j.mce.2026.112855

Genes

ERBB3
FGFR1
FTO
KLF16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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