Article
Abnormal nodal flow precedes situs inversus in iv and inv mice.
Molecular cell - 1 Oct 1999
Okada Y, Nonaka S, Tanaka Y, Saijoh Y, Hamada H, Hirokawa N
Abstract excerpt
We examined the nodal flow of well-characterized mouse mutants, inversus viscerum (iv) and inversion of embryonic turning (inv), and found that their laterality defects are always accompanied by an abnormality in nodal flow. In a randomized laterality mutant, iv, the nodal cilia were immotile and the nodal flow was absent. In a situs inversus mutant, inv, the nodal cilia was motile but could only produce very...
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