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Article

Mechanism for generation of left isomerism in Ccdc40 mutant embryos.

PloS one - 1 Jan 2017

Sugrue Kelsey F, Zohn Irene E

Abstract excerpt

Leftward fluid flow in the mouse node is generated by cilia and is critical for initiating asymmetry of the left-right axis. Coiled-coil domain containing-40 (Ccdc40) plays an evolutionarily conserved role in the assembly of motile cilia and establishment of the left-right axis. Approximately one-third of Ccdc40lnks mutant embryos display situs defects and here we investigate the underlying mechanism. Ccdc40lnks...

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PMID: 28182636
DOI: 10.1371/journal.pone.0171180
PMCID: PMC5300185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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