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Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs.

PLoS biology - 1 Mar 2026

Hsieh Yu-Ying Phoebe, O'Keefe Ian P, Wang Zeqi, Sun Wanting, Yang Hyojik, Vu Linda M, Smalley Nicole E, Ernst Robert K, Dandekar Ajai A, Malik Harmit S

Abstract excerpt

Increasing bacterial resistance to colistin, a vital last-resort antibiotic, is an urgent challenge. Previous studies have shown that Mg2+ depletion enables Pseudomonas aeruginosa to become resistant to colistin. Here, we show that magnesium sequestration by Candida albicans also enables P. aeruginosa to evolve a nearly hundredfold higher level of colistin resistance through genetic changes in lipid A...

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Anti-Bacterial Agents
Candida albicans
Colistin
Drug Resistance, Bacterial
Lipid A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Pseudomonas aeruginosa

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Identifiers

PMID: 41774708
DOI: 10.1371/journal.pbio.3003673
PMCID: PMC12998950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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