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(p)ppGpp/GTP and malonyl-CoA modulate <i>Staphylococcus aureus</i> adaptation to FASII antibiotics and provide a basis for synergistic bi-therapy

2020-03-27

Abstract excerpt

Fatty acid biosynthesis (FASII) enzymes are considered valid targets for antimicrobial drug development against the human pathogen Staphylococcus aureus . However, incorporation of host fatty acids confers FASII antibiotic adaptation that compromises prospective treatments. S. aureus adapts to FASII inhibitors by a first non-replicative latency period followed by outgrowth. Here we used transcriptional fusions a...

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Literature Corpus work
eba42a3b-1904-57ed-b480-e2447faa0ad3
DOI
10.1101/2020.03.26.007567
Open publication

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(p)ppGpp/GTP and malonyl-CoA modulate <i>Staphylococcus aureus</i> adaptation to FASII antibiotics and provide a basis for synergistic bi-therapyDOI 10.1101/2020.03.26.007567
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