Article
RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference.
American journal of human genetics - 8 Aug 2013
Maples Brian K, Gravel Simon, Kenny Eimear E, Bustamante Carlos D
Abstract excerpt
Local-ancestry inference is an important step in the genetic analysis of fully sequenced human genomes. Current methods can only detect continental-level ancestry (i.e., European versus African versus Asian) accurately even when using millions of markers. Here, we present RFMix, a powerful discriminative modeling approach that is faster (~30×) and more accurate than existing methods. We accomplish this by using a...
Topics
- Asian People
- Black People
- Computer Simulation
- Genetic Testing
- Genome, Human
- Haplotypes
- Humans
- Indians, North American
- Models, Genetic
- Polymorphism, Single Nucleotide
- White People