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Article

Structural basis of PLPP3-mediated lipid phosphate dephosphorylation and its role in melanoma.

Nature communications - 20 Jul 2026

Wu Yingjie, Xiao Di, Li Xingfan, Wang Keyu, Zhang Hongxu, Zhao Yuanyuan, Wu Di, Qi Ruxi, Zhou Mi, Han Han, Long Tao

Abstract excerpt

Lipid phosphates serve as signaling molecules involved in diverse cellular processes such as cell proliferation, migration, angiogenesis, inflammation, immunity and cancer progression. Phospholipid phosphatases (PLPPs) modulate these signals by catalyzing the dephosphorylation of lipid phosphates. Here, we report the cryo-EM structure of PLPP3, revealing a tetrameric assembly. PLPP3 contains six transmembrane...

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Cryoelectron Microscopy
Melanoma
Models, Molecular
Mutation
Phosphatidate Phosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

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Identifiers

PMID: 42477009
DOI: 10.1038/s41467-026-75824-w
PMCID: PMC13500480

Genes

PLPP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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