Article
Identification of PGAM5 as a Mammalian Protein Histidine Phosphatase that Plays a Central Role to Negatively Regulate CD4(+) T Cells.
Molecular cell - 4 Aug 2016
Panda Saswati, Srivastava Shekhar, Li Zhai, Vaeth Martin, Fuhs Stephen R, Hunter Tony, Skolnik Edward Y
Abstract excerpt
Whereas phosphorylation of serine, threonine, and tyrosine is exceedingly well characterized, the role of histidine phosphorylation in mammalian signaling is largely unexplored. Here we show that phosphoglycerate mutase family 5 (PGAM5) functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B). By...
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