INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.

doi:10.1038/s43018-023-00710-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.

Nature cancer - 1 Mar 2024

Elbatsh Ahmed M O, Amin-Mansour Ali, Haberkorn Anne, Textor Claudia, Ebel Nicolas, Renard Emilie, Koch Lisa M, Groenveld Femke C, Piquet Michelle, Naumann Ulrike, Ruddy David A, Romanet Vincent, Martínez Gómez Julia M, Shirley Matthew D, Wipfli Peter, Schnell Christian, Wartmann Markus, Rausch Martin, Jager Martine J, Levesque Mitchell P, Maira Sauveur-Michel, Manchado Eusebio

Abstract excerpt

Activating mutations in GNAQ/GNA11 occur in over 90% of uveal melanomas (UMs), the most lethal melanoma subtype; however, targeting these oncogenes has proven challenging and inhibiting their downstream effectors show limited clinical efficacy. Here, we performed genome-scale CRISPR screens along with computational analyses of cancer dependency and gene expression datasets to identify the inositol-metabolizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Melanoma

Share to Mutation

Share to Ocular Oncology and Treatments

Share to Retinal Development and Disorders

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 38233483
DOI: 10.1038/s43018-023-00710-z
PMCID: PMC10965444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.PMID 38233483Read ↗

Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses.Semantic proximity Read ↗

Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell deathSemantic proximity Read ↗

GNAQ/11 mutations in uveal melanoma: is YAP the key to targeted therapy?Semantic proximity Read ↗

Examination of INPP5A in uveal melanoma uncovers novel calcium transientsSemantic proximity Read ↗

Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner.Semantic proximity Read ↗

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.Semantic proximity Read ↗

GNAQ and GNA11 mutations in uveal melanoma.Semantic proximity Read ↗

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitrySemantic proximity Read ↗

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal MelanomaSemantic proximity Read ↗

Inherited duplications of <i>PPP2R3B</i> promote naevi and melanoma via a novel <i>C21orf91</i> -driven proliferative phenotypeSemantic proximity Read ↗

Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in MiceSemantic proximity Read ↗

MITF deficiency accelerates GNAQ-driven uveal melanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.