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Article

A ZDHHC3-USP5-PTRF axis links palmitoylation to ferroptosis-associated phenotypes in melanoma.

Cell death & disease - 2 Jul 2026

Zhao Songyun, Liu Yuankun, Wu Dan, Ma Chenfeng, Luo Peng, Zhang Pengpeng, He Yucang, Liang Xiaoqing, Cheng Chao, Xie Jiaheng, Li Liqun

Abstract excerpt

Melanoma is a highly aggressive malignancy with poor prognosis and therapy resistance. Although deubiquitinating enzymes (DUBs) regulate protein stability and cancer progression, their modulation in melanoma remains unclear. Here, we characterized ubiquitin‑specific peptidase 5 (USP5) using proteomic, biochemical, and functional approaches. USP5 was upregulated in melanoma and promoted proliferation, migration,...

Read the complete abstract on PubMed

Topics

Humans
Melanoma
Lipoylation
Acyltransferases
Animals
Ferroptosis
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line, Tumor

Ubiquitination

Membrane Proteins

Mice

Ubiquitin-Specific Proteases

Cell Proliferation

Mice, Nude

Endopeptidases

Source

Open in PubMed Open full text

Identifiers

PMID: 42393029
DOI: 10.1038/s41419-026-09053-w
PMCID: PMC13597508

Genes

USP5
ZDHHC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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