Article

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

2020-09-19

Abstract excerpt

<h4>SUMMARY</h4> Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target and a hub for crosstalk regulation, little is known about dephosphorylation of MEK, the central kinase within the cascade. Here, we identify PPP6C, a phosphatase frequently mutated or downregulated in melanoma, as a major MEK phosphat...

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Literature Corpus work: ed8178f2-434b-52d4-af42-66707d144a30
DOI: 10.1101/2020.09.18.303859

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