Tyrosine phosphatase activity is restricted by basic charge substituting mutation of substrates.

Abstract excerpt

Phosphorylation controls important cellular signals and its dysregulation leads to disease. While most phospho-regulation studies are focused on kinases, phosphatases are comparatively overlooked. Combining peptide arrays with SAMDI mass spectrometry, we show that tyrosine phosphatase activity is restricted by basic amino acids adjacent to phosphotyrosines. We validate this model using two β-catenin mutants...

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• beta Catenin
• Mice
• Mutation
• Phosphorylation
• Protein Tyrosine Phosphatases
• Tyrosine