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Article

Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability

11 Dec 2017

Abstract excerpt

Lysyl oxidase-like 3 (LOXL3) is a member of the lysyl oxidase family comprising multifunctional enzymes with depicted roles in extracellular matrix maturation, tumorigenesis, and metastasis. In silico expression analyses followed by experimental validation in a comprehensive cohort of human cell lines revealed a significant upregulation of LOXL3 in human melanoma. We show that LOXL3 silencing impairs cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29229995
DOI: 10.1038/s41418-017-0030-2

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