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Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase

21 Jun 2016

Abstract excerpt

Phosphatase of regenerating liver (PRL) oncoproteins are phosphatases overexpressed in numerous types of human cancer. Elevated levels of PRL associate with metastasis and poor clinical outcomes. In principle, PRL phosphatases offer appealing therapeutic targets, but they remain underexplored due to the lack of specific chemical probes. In this study, we address this issue by exploiting a unique property of PRL...

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PMID: 27325652
DOI: 10.1158/0008-5472.can-15-2323

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