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Article

Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition.

Molecular cancer research : MCR - 1 Apr 2021

Nussinov Ruth, Zhang Mingzhen, Tsai Chung-Jung, Jang Hyunbum

Abstract excerpt

PI3K and PTEN are the second and third most highly mutated proteins in cancer following only p53. Their actions oppose each other. PI3K phosphorylates signaling lipid PIP2 to PIP3 PTEN dephosphorylates it back. Driver mutations in both proteins accrue PIP3 PIP3 recruits AKT and PDK1 to the membrane, promoting cell-cycle progression. Here we review phosphorylation events and mutations in autoinhibition in PI3K and...

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Identifiers

PMID: 33288731
DOI: 10.1158/1541-7786.MCR-20-0818
PMCID: PMC8026595

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