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Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer

6 Feb 2025

Abstract excerpt

The development of metastasis is a leading cause of cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus of cancer cells. Elevated levels of membrane lipids, including sphingomyelin, cholesterol, and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), in the PM, contribute to changes in membrane rigidity, lipid raft formation, and actin polymerisation dynamics, processes that...

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PMID: 39915829
DOI: 10.1186/s12944-025-02452-6

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