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Article

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality

9 Feb 2021

Abstract excerpt

AIMS: Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality...

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PMID: 33748830
DOI: 10.1093/eurheartj/ehab107

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