Beyond traditional criteria: CRP and fibrinogen as biomarkers of metabolic syndrome in ART-treated people living with HIV and their association with HIF-1α rs11549465.

doi:10.1371/journal.pone.0357899

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Article

Beyond traditional criteria: CRP and fibrinogen as biomarkers of metabolic syndrome in ART-treated people living with HIV and their association with HIF-1α rs11549465.

PloS one - 1 Jan 2026

Đorđević Nemanja, Ranin Jovan, Gmizić Ivana, Ljujić Biljana, Marković Marko, Rajković Ivan, Ranin Jovana, Raković Ivana, Sekulić Marković Sofija, Popovska Jovičić Biljana

Abstract excerpt

Metabolic syndrome (MS) is highly prevalent among people living with HIV (PLWH) receiving antiretroviral therapy (ART) and is driven by persistent low-grade inflammation. Hypoxia-inducible factor 1 alpha (HIF-1α) polymorphisms may influence inflammatory pathways underlying MS. This study investigated the association of the rs11549465 HIF-1α polymorphism with inflammatory markers and MS in PLWH receiving ART. We...

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Topics

Humans
Fibrinogen
C-Reactive Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Metabolic Syndrome

Male

Hypoxia-Inducible Factor 1, alpha Subunit

Biomarkers

HIV Infections

Middle Aged

Adult

Case-Control Studies

Polymorphism, Single Nucleotide

Genotype

Source

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Identifiers

PMID: 42709845
DOI: 10.1371/journal.pone.0357899
PMCID: PMC13552767

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