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Article

Evidence for a Constrained Mutational Pathway to High-Level Spectinomycin Resistance in Neisseria: RpsE Loop 2 Mutations and Associated Growth Costs.

International journal of molecular sciences - 3 Jul 2026

Kravtsov Dmitry V, Gryadunov Dmitry A, Anashkina Anastasia A, Shaskolskiy Boris L

Abstract excerpt

Antimicrobial resistance in Neisseria gonorrhoeae is a global concern. Spectinomycin is unusual in that resistance can emerge rapidly during localized outbreaks yet often disappears from clinical populations after drug withdrawal, suggesting an associated growth cost. To investigate evolutionary routes to spectinomycin resistance, we performed in vitro selection on two N. gonorrhoeae strains and two commensal...

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Identifiers

PMID: 42450237
DOI: 10.3390/ijms27135971
PMCID: PMC13361928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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