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Article

Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy - 1 Apr 2026

Yao Linxin, Tian Tingli, Zou Danyang, Lu Xinying, Jiang Nanyan, Feng Xin, Zheng Tong, Tang Zhuojun, Lin Yi, Ning Zhen, Jiang Jianping, Ye Meiping, Zhou Pingyu

Abstract excerpt

Although gepotidacin is a promising oral candidate for treating multidrug-resistant Neisseria gonorrhoeae, its resistance mechanisms and clinical implications remain poorly understood. In this study, we collected 989 clinical N. gonorrhoeae isolates from 33 hospitals in Shanghai, China (2022-2024). Antimicrobial susceptibility testing showed that gepotidacin exhibited high in vitro activity with MIC50 and MIC90...

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Identifiers

PMID: 41810969
DOI: 10.1128/aac.01706-25
PMCID: PMC13041355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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