Article
A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase.
Microbiology spectrum - 4 Jun 2024
Balthazar Jacqueline T, Golparian Daniel, Unemo Magnus, Read Timothy D, Grosse Miriam, Stadler Marc, Pfarr Kenneth, Schiefer Andrea, Hoerauf Achim, Edwards Jennifer L, Vassylyev Dmitry G, Shafer William M
Abstract excerpt
The continued emergence of Neisseria gonorrhoeae strains that express resistance to multiple antibiotics, including the last drug for empiric monotherapy (ceftriaxone), necessitates the development of new treatment options to cure gonorrheal infections. Toward this goal, we recently reported that corallopyronin A (CorA), which targets the switch region of the β' subunit (RpoC) of bacterial DNA-dependent RNA...
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