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Constrained evolutionary paths to macrolide resistance in a <i>Neisseria</i> commensal converge on ribosomal genes through sequence duplication

2021-04-06

Abstract excerpt

Neisseria commensals are an indisputable source of resistance for their pathogenic relatives; however, the evolutionary paths commensal species take to reduced susceptibility in this genus have been relatively underexplored. Here, we leverage in vitro selection as a powerful screen to identify the genetic adaptations that produce azithromycin resistance (≤ 2 μg/mL) in the Neisseria commensal, N. elongata . Acro...

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Identifiers and source

Literature Corpus work
3dd993aa-0f4f-51b8-9bbf-7d4b31ce0325
DOI
10.1101/2021.04.05.438469
Open publication

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Constrained evolutionary paths to macrolide resistance in a <i>Neisseria</i> commensal converge on ribosomal genes through sequence duplicationDOI 10.1101/2021.04.05.438469
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