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In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae.

mBio - 3 Apr 2018

Vincent Leah R, Kerr Samuel R, Tan Yang, Tomberg Joshua, Raterman Erica L, Dunning Hotopp Julie C, Unemo Magnus, Nicholas Robert A, Jerse Ann E

Abstract excerpt

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduced the mosaic penA alleles from two ceftriaxone-resistant (Cror) clinical isolates (H041 and F89) into a Cros strain (FA19) by...

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Identifiers

PMID: 29615507
DOI: 10.1128/mBio.01905-17
PMCID: PMC5885032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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