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Article

Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In Vitro Study of Mechanisms Associated with rpoB H553Y Mutation.

Antimicrobial agents and chemotherapy - 1 Dec 2015

Colicchio Roberta, Pagliuca Chiara, Pastore Gabiria, Cicatiello Annunziata Gaetana, Pagliarulo Caterina, Talà Adelfia, Scaglione Elena, Sammartino Josè Camilla, Bucci Cecilia, Alifano Pietro, Salvatore Paola

Abstract excerpt

Rifampin chemoprophylaxis against Neisseria meningitidis infections led to the onset of rifampin resistance in clinical isolates harboring point mutations in the rpoB gene, coding for the RNA polymerase β chain. These resistant strains are rare in medical practice, suggesting their decreased fitn...

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Identifiers

PMID: 26416867
DOI: 10.1128/AAC.01746-15
PMCID: PMC4649176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26416867-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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