Article
Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.
Biochemistry - 28 Feb 2017
Tomberg Joshua, Fedarovich Alena, Vincent Leah R, Jerse Ann E, Unemo Magnus, Davies Christopher, Nicholas Robert A
Abstract excerpt
Resistance of Neisseria gonorrhoeae to expanded-spectrum cephalosporins such as ceftriaxone and cefixime has increased markedly in the past decade. The primary cephalosporin resistance determinant is a mutated penA gene, which encodes the essential peptidoglycan transpeptidase, penicillin-binding protein 2 (PBP2). Decreased susceptibility and resistance can be conferred by mosaic penA alleles containing upward of...
Topics
- Alanine
- Alleles
- Catalytic Domain
- Cephalosporin Resistance
- Hydrogen Bonding
- Microbial Sensitivity Tests
- Models, Molecular
- Mutation
- Neisseria gonorrhoeae
- Penicillin-Binding Proteins
- Protein Stability
- Temperature