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Article

Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism.

Antimicrobial agents and chemotherapy - 1 Oct 2016

Huang Kaisong, Zhang Qiang, Song Yajing, Zhang Zhewen, Zhang Anding, Xiao Jingfa, Jin Meilin

Abstract excerpt

Spectinomycin is an aminocyclitol antibiotic used clinically to treat a variety of infections in animals. Here, we characterized drug resistance prevalence in clinical Streptococcus suis isolates and discovered a novel resistance mechanism in which the s5 mutation (Gly26Asp) results in high spectinomycin resistance. Additionally, a novel integrative and conjugative element encompassing a multidrug resistance...

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Identifiers

PMID: 27458226
DOI: 10.1128/AAC.01157-16
PMCID: PMC5038275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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