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Article

Alternate genetic paths of adaptation to spectinomycin in Escherichia coli.

Genetics - 12 Nov 2025

Jena Chinmaya, Deolankar Soham, Matange Nishad

Abstract excerpt

Unregulated antibiotic use leads to their accumulation in the environment at sublethal levels, facilitating the evolution of antimicrobial resistance in bacteria. Antibiotics used in farms and veterinary medicine are frequently detected in soil and water, though genetic adaptations to them in human-relevant bacteria are poorly characterized. In this study, we investigated adaptation of Escherichia coli to low...

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PMID: 40205803
DOI: 10.1093/genetics/iyaf069

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