Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts.

doi:10.1016/j.ajhg.2026.06.014

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Article

Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts.

American journal of human genetics - 6 Aug 2026

Naderian Mohammadreza, Smith Johanna L, Dikilitas Ozan, Hamed Marwan E, Abul-Husn Noura S, Connolly John J, Cortopassi Josh B, Feng Qiping, Hanks Sarah C, Irvin Ryan, Jarvik Gail P, Kenny Eimear E, Khan Atlas, Kottyan Leah C, Limdi Nita A, McNally Elizabeth M, Miller Emily, Namjou-Khales Bahram, Roy-Puckelwartz Megan, Rowley Robb, Tiwari Hemant K, Wei Wei-Qi, Wiesner Georgia, Manolio Teri A, Sharp Richard R, Kullo Iftikhar J

Abstract excerpt

Whether polygenic risk, monogenic familial hypercholesterolemia (FH), and family history (FamHx) are additively informative for coronary heart disease (CHD) risk prediction across self-identified race/ethnicity (SIRE) groups has not been established. In two diverse cohorts-Electronic Medical Records and Genomics (eMERGE) phase IV (eIV; n = 19,348) and All of Us (AoU; n = 239,645)-we quantified the associations of...

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PMID: 42447869
DOI: 10.1016/j.ajhg.2026.06.014
PMCID: PMC13504335

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