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Article

Polygenic Risk, Rare Variants, and Family History

26 Aug 2023

Abstract excerpt

Genetic factors are not included in prediction models for coronary heart disease (CHD). The authors assessed the predictive utility of a polygenic risk score (PRS) for CHD (defined as myocardial infarction, coronary revascularization, or cardiovascular death) and whether the risks due to monogenic familial hypercholesterolemia (FH) and family history (FamHx) are independent of and additive to the PRS. In...

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Identifiers

PMID: 38939477
DOI: 10.1016/j.jacadv.2023.100567

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