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Article

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 May 2018

Imgenberg-Kreuz Juliana, Carlsson Almlöf Jonas, Leonard Dag, Alexsson Andrei, Nordmark Gunnel, Eloranta Maija-Leena, Rantapää-Dahlqvist Solbritt, Bengtsson Anders A, Jönsen Andreas, Padyukov Leonid, Gunnarsson Iva, Svenungsson Elisabet, Sjöwall Christopher, Rönnblom Lars, Syvänen Ann-Christine, Sandling Johanna K

Abstract excerpt

OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with heterogeneous presentation and complex aetiology where DNA methylation changes are emerging as a contributing factor. In order to discover novel epigenetic associations and investigate their relationship to genetic risk for SLE, we analysed DNA methylation profiles in a large collection of patients with SLE and healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29437559
DOI: 10.1136/annrheumdis-2017-212379
PMCID: PMC5909746

Genes

IKZF3
PTPRC

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