Genetic and epigenetic determinants of relapse risk in lupus nephritis.

doi:10.1136/lupus-2026-002043

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Article

Genetic and epigenetic determinants of relapse risk in lupus nephritis.

Lupus science & medicine - 1 Sept 2026

Skoglund Elisabeth, Skoglund Oliver, Vestin Holme, Oparina Nina, Sayadi Ahmed, Faustini Francesca, Svenungsson Elisabet, Ronnblom Lars, Svensson Maria K, Imgenberg-Kreuz Juliana, Gunnarsson Iva, Sjöwall Christopher, Leonard Dag

Abstract excerpt

OBJECTIVE: Lupus nephritis (LN) is a potentially severe manifestation of SLE, often resulting in permanent kidney damage. We investigated whether polygenic and/or epigenetic risk is associated with time to LN relapse and whether this association differs by initial therapy. METHODS: Caucasian patients with biopsy-verified LN between 1974 and 2022 (n=149) were genotyped using the Illumina Global Screening Array,...

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Topics

Humans
Lupus Nephritis
Female
Recurrence
Genetic Risk Score
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Epigenesis, Genetic

DNA Methylation

Genetic Predisposition to Disease

Immunosuppressive Agents

Cyclophosphamide

Proportional Hazards Models

Risk Factors

Middle Aged

Source

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Identifiers

PMID: 42680511
DOI: 10.1136/lupus-2026-002043
PMCID: PMC13536080

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