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Article

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer

2 Mar 2020

Abstract excerpt

Ultraviolet (UV) radiation is among the most prevalent environmental factors that influence human health and disease. Even 1 h of UV irradiation extensively damages the genome. To cope with resulting deleterious DNA lesions, cells activate a multitude of DNA damage response pathways, including DNA repair. Strikingly, UV-induced DNA damage formation and repair are affected by chromatin state. When cells enter S...

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PMID: 32119110
DOI: 10.1111/php.13245

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