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Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses

17 Feb 2017

Abstract excerpt

To elucidate the complex molecular mechanisms underlying the adverse effects UV radiation (UVR) on skin homeostasis, we performed multi-omics studies to characterize UV-induced genetic and epigenetic changes. Human keratinocytes from a single donor treated with or without UVR were analyzed by RNA-seq, exome-seq, and H3K27ac ChIP-seq at 4 h and 72 h following UVR. Compared to the relatively moderate mutagenic...

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PMID: 28211524
DOI: 10.1038/srep42646

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