Article
H2BE113K mutation promotes breast cancer metastasis through modulating chromatin dynamics.
Science advances - 10 Jul 2026
Hu 胡诗曼 Shiman, Liu Jiaxian, Zhou Jiaqi, Chen Jiaohua, Qin Tiantian, Wan Yi Ching Esther, Zhu Xiaoxuan, Wang Danyi, Shao Chuting, Chen Yabin, Wang Xin, Han Junhong, Wong Hoi Leong Xavier, Weiss Robert S, Jin Haojie, Chen Mo, Li Qing, Saunthararajah Yogen, Gan Haiyun, Chan 陈居明 Kui Ming
Abstract excerpt
Cancer progression is driven by the accumulation of DNA mutations and aberrant gene regulation. Recent studies have demonstrated that multiple H3 mutations serve as drivers of tumorigenesis. However, the role and significance of various cancer-associated histone H2B mutations in cancer development remain unknown. Here, we investigate H2BE113K, a missense mutation of histone H2B predominantly found in patients...
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