Histone Mutations and Bone Cancers.

Abstract excerpt

Primary bone tumors are rare cancers that cause significant morbidity and mortality. The recent identification of recurrent mutations in histone genes H3F3A and H3F3B within specific bone cancers, namely, chondroblastomas and giant cell tumors of bone (GCTB), has provided insights into the cellular and molecular origins of these neoplasms and enhanced understanding of how histone variants control chromatin...

Topics

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• Bone Neoplasms
• Histone-Lysine N-Methyltransferase
• Histones
• Mutation
• Repressor Proteins