Article
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.
The Journal of biological chemistry - 1 Jan 2000
Kang Tze Zhen Evangeline, Zhu Lina, Yang Du, Ding Dongbo, Zhu Xiaoxuan, Wan Yi Ching Esther, Liu Jiaxian, Ramakrishnan Saravanan, Chan Landon Long, Chan Siu Yuen, Wang Xin, Gan Haiyun, Han Junhong, Ishibashi Toyotaka, Li Qing, Chan Kui Ming
Abstract excerpt
The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone. H2BE76K weakens the stability of histone octamers, alters gene expression, and promotes colony formation. However, the mechanism linking the H2BE76K mutation to cancer development remains largely unknown. In this study, we knock in the H2BE76K mutation in...
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