Article
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.
Nucleic acids research - 2 Nov 2018
Arimura Yasuhiro, Ikura Masae, Fujita Risa, Noda Mamiko, Kobayashi Wataru, Horikoshi Naoki, Sun Jiying, Shi Lin, Kusakabe Masayuki, Harata Masahiko, Ohkawa Yasuyuki, Tashiro Satoshi, Kimura Hiroshi, Ikura Tsuyoshi, Kurumizaka Hitoshi
Abstract excerpt
Mutations of the Glu76 residue of canonical histone H2B are frequently found in cancer cells. However, it is quite mysterious how a single amino acid substitution in one of the multiple H2B genes affects cell fate. Here we found that the H2B E76K mutation, in which Glu76 is replaced by Lys (E76K), distorted the interface between H2B and H4 in the nucleosome, as revealed by the crystal structure and induced...
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